The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival.
Hyaluronan (HA) is a major extracellular matrix component whose tissue levels are dynamically regulated during embryonic development.Although the synthesis of HA has been shown to exert a substantial influence on embryonic morphogenesis, the functional importance of the catabolic aspect of HA turnover is poorly understood.Here, we demonstrate that